EUCRISA works above and below the skin’s surface

When EUCRISA was approved in 2016, it was the first FDA-approved topical prescription treatment for eczema in over a decade. It is a steroid-free ointment for people with mild-to-moderate eczema and can be used on all skin tones from nose to toes, for adults and kids as young as 3 months old. EUCRISA is for topical use only. Do not use in eyes, mouth, or vagina.

You can see eczema on the surface of your skin, but there may also be irritation below that you can’t see. EUCRISA works both above and below the skin to treat eczema.

The active ingredient, crisaborole 2%, acts deep within your skin cells to target an enzyme called PDE4 (phosphodiesterase 4). The specific way EUCRISA works is not well defined.

Crisaborole is combined with our proprietary Emollient-Rich Vehicle ointment. Ointments contain emollients, which can help lock in moisture and soften the skin.

Have more questions? See how telemedicine may help you get answers.

how EUCRISA® (crisaborole) works above and below the skin surface
how EUCRISA® (crisaborole) works above and below the skin surface
how EUCRISA® (crisaborole) works above and below the skin surface

Learn how EUCRISA works above and below the skin's surface


100% steroid free

Is 100% steroid free

no added fragrance

Has no added fragrance

paraben free

Is paraben free

contains no animal by-products

Contains no animal

corona msg

Important Safety Information & Indication


Do not use EUCRISA if you are allergic to crisaborole or any of the ingredients in EUCRISA.

EUCRISA may cause side effects including allergic reactions at or near the application site. These can be serious and may include hives, itching, swelling, and redness. If you have any of these symptoms, stop using EUCRISA and get medical help right away.

The most common side effect of EUCRISA is application site pain, such as burning or stinging.

EUCRISA is for use on skin (topical use) only. Do not use EUCRISA in your eyes, mouth, or vagina.

EUCRISA is a prescription ointment used on the skin (topical) to treat mild-to-moderate eczema (atopic dermatitis) in adults and children 3 months of age and older.

See Full Prescribing Information .