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What is PDE4 anyway?

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PDE4 is an enzyme that helps to regulate inflammation in your body. When you have eczema, PDE4 enzymes may be overactive in your skin cells. This can lead to inflammation in your skin. Although the specific way EUCRISA works is not well defined, science shows us that it works differently by blocking overactive PDE4 enzymes within the skin cells. Blocking PDE4 is believed to reduce inflammation related to eczema.


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If you are looking for a different way to treat mild-to-moderate eczema for you or your child age 3 months and up, ask your dermatologist, allergist or primary care physician if steroid-free EUCRISA may be right for you. If your child has eczema, talk to their pediatrician about EUCRISA. If your doctor offers telemedicine visits, check out our tips on prepping for your call.

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Important Safety Information & Indication


Do not use EUCRISA if you are allergic to crisaborole or any of the ingredients in EUCRISA.

EUCRISA may cause side effects including allergic reactions at or near the application site. These can be serious and may include hives, itching, swelling, and redness. If you have any of these symptoms, stop using EUCRISA and get medical help right away.

The most common side effect of EUCRISA is application site pain, such as burning or stinging.

EUCRISA is for use on skin (topical use) only. Do not use EUCRISA in your eyes, mouth, or vagina.

EUCRISA is a prescription ointment used on the skin (topical) to treat mild-to-moderate eczema (atopic dermatitis) in adults and children 3 months of age and older.

See Full Prescribing Information .